Skin signs in acute pancreatitis: frequency and implications for prognosis.

Dear Sir, Subcutaneous manifestations of severe acute pancreatitis (Grey-Turner’s sign, Cullen’s sign, Fox’s sign and Walzel’s sign) are often discussed in journals and textbooks. The first two are mentioned even in textbooks ([1]; page 1897). However, despite the publication of several case reports of these skin signs, most physicians have never seen representative cases and therefore do not appreciate the clinical impact of these signs.